Tunneling mechanism of light transmission through metallic films

A mechanism of light transmission through metallic films is proposed, assisted by tunnelling between resonating buried dielectric inclusions. This is illustrated by arrays of Si spheres embedded in Ag. Strong transmission peaks are observed near the Mie resonances of the spheres. The interaction among various planes of spheres and interference effects between these resonances and the surface plasmons of Ag lead to mixing and splitting of the resonances. Transmission is proved to be limited only by absorption. For small spheres, the effective dielectric constant can be tuned to values close to unity and a method is proposed to turn the resulting materials invisible.Comment: 4 papges, 5 figure

Starbursts and Star Clusters in the Ultraviolet

Hubble Space Telescope ultraviolet (UV) images of nine starburst galaxies reveal them to be highly irregular, even after excluding compact sources (clusters and resolved stars). Most (7/9) are found to have a similar intrinsic effective surface brightnesses, suggesting that a negative feedback mechanism is setting an upper limit to the star formation rate per unit area. All starbursts in our sample contain UV bright star clusters indicating that cluster formation is an important mode of star formation in starbursts. On average about 20% of the UV luminosity comes from these clusters. The brightest clusters, or super star clusters (SSC), are preferentially found at the very heart of starbursts. The size of the nearest SSCs are consistent with those of Galactic globular clusters. The luminosity function of SSCs is well represented by a power law with a slope alpha ~ -2. There is a strong correlation between the far infrared excess and the UV spectral slope. The correlation is well modeled by a geometry where much of their dust is in a foreground screen near to the starburst, but not by a geometry of well mixed stars and dust.Comment: 47 pages, text only, LaTeX with aaspp.sty (version 3.0), compressed postscript figures available at ftp://eta.pha.jhu.edu/RecentPublications/meurer

The chemical composition of metal-poor emission-line galaxies in the Data Release 3 of the Sloan Digital Sky Survey

We have re-evaluated empirical expressions for the abundance determination of N, O, Ne, S, Cl, Ar and Fe taking into account the latest atomic data and constructing an appropriate grid of photoionization models with state-of-the art model atmospheres. Using these expressions we have derived heavy element abundances in the $\sim$ 310 emission-line galaxies from the Data Release 3 of the Sloan Digital Sky Survey (SDSS)with an observed Hbeta flux F(Hbeta)> 1E-14 erg s^{-1} cm^{-2} and for which the [O III] 4363 emission line was detected at least at a 2sigma level, allowing abundance determination by direct methods. The oxygen abundance 12 + log O/H of the SDSS galaxies lies in the range from ~ 7.1 (Zsun/30) to 8.5 (0.7 Zsun). The SDSS sample is merged with a sample of 109 blue compact dwarf (BCD) galaxies with high quality spectra, which contains extremely low-metallicity objects. We use the merged sample to study the abundance patterns of low-metallicity emission-line galaxies. We find that extremely metal-poor galaxies (12 + log O/H < 7.6, i.e. Z < Zsun/12) are rare in the SDSS sample. The alpha element-to-oxygen abundance ratios do not show any significant trends with oxygen abundance, in agreement with previous studies, except for a slight increase of Ne/O with increasing metallicity, which we interpret as due to a moderate depletion of O onto grains in the most metal-rich galaxies. The Fe/O abundance ratio is smaller than the solar value, by up to 1 dex at the high metallicity end. (abridged)Comment: 17 pages, 12 figures. Accepted for publication in the Astronomy and Astrophysic

Parental Rights and Religious Liberty: Examining New Conflicts Between Parents and the State

The Supreme Court has articulated that parents have the unenumerated right rooted in the Fourteenth Amendment to direct the care, custody, and upbringing of their children since the 1920s in such cases as Pierce v. Society of Sisters, Meyer v. Nebraska, Parham v. J.R. and Troxel v. Granville. However, the precise contours of the right have long been uncertain, as has the level of scrutiny to be applied. In Dobbs v. Jackson Women’s Health Organization, the Supreme Court established a clear threshold for unenumerated rights, that they must be rooted in history and tradition and essential to ordered liberty. The Court noted that its decision does not call into question its line of cases on parental rights. Nevertheless, the question remains: do parental rights meet the Court’s threshold? Are there reasons to believe that parental rights will be affected by the Dobbs decision? The Dobbs decision comes as a new series of conflicts between parents and the state are arising in education and healthcare around the country. Many of these conflicts over ideas about gender and race. These new conflicts implicate parental rights and are raising questions for courts such as: Who has the primary responsibility for the formation of a child’s identity and values? Do parental rights extend beyond the schoolhouse gate to include instruction and policies in schools? And who gets to decide the treatment of a child’s mental health, including gender distress? These questions and more have been raised in a series of recent lawsuits against school districts over policies concerning race and gender-based curriculum and policies where challengers have invoked parental rights theories. How do those arguments square with existing doctrine? How might they extend existing doctrine

Taking the self out of self-rule

Many philosophers believe that agents are self-ruled only when ruled by their (authentic) selves. Though this view is rarely argued for explicitly, one tempting line of thought suggests that self-rule is just obviously equivalent to rule by the self. However, the plausibility of this thought evaporates upon close examination of the logic of ‘self-rule’ and similar reflexives. Moreover, attempts to rescue the account by recasting it in negative terms are unpromising. In light of these problems, this paper instead proposes that agents are self-ruled only when not ruled by others. One reason for favouring this negative social view is its ability to yield plausible conclusions concerning various manipulation cases that are notoriously problematic for nonsocial accounts of self-rule. A second reason is that the account conforms with ordinary usage. It is concluded that self-rule may be best thought of as an essentially social concept

WR bubbles and HeII emission

We present the very first high quality images of the HeII 4686 emission in three high excitation nebulae of the Magellanic Clouds. A fourth high excitation nebula, situated around the WR star BAT99-2, was analysed in a previous letter. Using VLT FORS data, we investigate the morphology of the ring nebulae around the early-type WN stars BAT99-49 & AB7. We derive the total HeII fluxes for each object and compare them with the most recent theoretical WR models. Using Halpha, [OIII] and HeI 5876 images along with long-slit spectroscopy, we investigate the physical properties of these ring nebulae and find only moderate chemical enrichment. We also surveyed seven other LMC WR stars but we failed to detect any HeII emission but note that the nebula around BAT99-11 shows a N/O ratio and an oxygen abundance slightly lower than the LMC values, while the nebula around BAT99-134 presents moderate chemical enrichment similar to the one seen near BAT99-2, 49 and AB7. The third high excitation nebula presented in this paper, N44C, does not harbor stars hotter than mid-O main sequence stars. It was suggested to be a fossil X-ray nebula ionized but our observations of N44C reveal no substantial changes in the excitation compared to previous results reported in the literature.Comment: 13 pages, 8 figures (7 in jpg), accepted by A&A, also available from http://vela.astro.ulg.ac.be/Preprints/P81/index.htm

Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth.

Lung disease and elevation of blood glucose are associated with increased glucose concentration in the airway surface liquid (ASL). Raised ASL glucose is associated with increased susceptibility to infection by respiratory pathogens including Staphylococcus aureus and Pseudomonas aeruginosa. We have previously shown that the anti-diabetes drug, metformin, reduces glucose-induced S. aureus growth across in vitro airway epithelial cultures. The aim of this study was to investigate whether metformin has the potential to reduce glucose-induced P. aeruginosa infections across airway epithelial (Calu-3) cultures by limiting glucose permeability. We also explored the effect of P. aeruginosa and metformin on airway epithelial barrier function by investigating changes in tight junction protein abundance. Apical P. aeruginosa growth increased with basolateral glucose concentration, reduced transepithelial electrical resistance (TEER) and increased paracellular glucose flux. Metformin pre-treatment of the epithelium inhibited the glucose-induced growth of P. aeruginosa, increased TEER and decreased glucose flux. Similar effects on bacterial growth and TEER were observed with the AMP activated protein kinase agonist, 5-aminoimidazole-4-carboxamide ribonucleotide. Interestingly, metformin was able to prevent the P. aeruginosa-induced reduction in the abundance of tight junction proteins, claudin-1 and occludin. Our study highlights the potential of metformin to reduce hyperglycaemia-induced P. aeruginosa growth through airway epithelial tight junction modulation, and that claudin-1 and occludin could be important targets to regulate glucose permeability across airway epithelia and supress bacterial growth. Further investigation into the mechanisms regulating metformin and P. aeruginosa action on airway epithelial tight junctions could yield new therapeutic targets to prevent/suppress hyperglycaemia-induced respiratory infections, avoiding the use of antibiotics

Identification and utilization of arbitrary correlations in models of recombination signal sequences

BACKGROUND: A significant challenge in bioinformatics is to develop methods for detecting and modeling patterns in variable DNA sequence sites, such as protein-binding sites in regulatory DNA. Current approaches sometimes perform poorly when positions in the site do not independently affect protein binding. We developed a statistical technique for modeling the correlation structure in variable DNA sequence sites. The method places no restrictions on the number of correlated positions or on their spatial relationship within the site. No prior empirical evidence for the correlation structure is necessary. RESULTS: We applied our method to the recombination signal sequences (RSS) that direct assembly of B-cell and T-cell antigen-receptor genes via V(D)J recombination. The technique is based on model selection by cross-validation and produces models that allow computation of an information score for any signal-length sequence. We also modeled RSS using order zero and order one Markov chains. The scores from all models are highly correlated with measured recombination efficiencies, but the models arising from our technique are better than the Markov models at discriminating RSS from non-RSS. CONCLUSIONS: Our model-development procedure produces models that estimate well the recombinogenic potential of RSS and are better at RSS recognition than the order zero and order one Markov models. Our models are, therefore, valuable for studying the regulation of both physiologic and aberrant V(D)J recombination. The approach could be equally powerful for the study of promoter and enhancer elements, splice sites, and other DNA regulatory sites that are highly variable at the level of individual nucleotide positions

Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid.

Hyperglycaemia as a result of diabetes mellitus or acute illness is associated with increased susceptibility to respiratory infection with Staphylococcus aureus. Hyperglycaemia increases the concentration of glucose in airway surface liquid (ASL) and promotes the growth of S. aureus in vitro and in vivo. Whether elevation of other sugars in the blood, such as fructose, also results in increased concentrations in ASL is unknown and whether sugars in ASL are directly utilised by S. aureus for growth has not been investigated. We obtained mutant S. aureus JE2 strains with transposon disrupted sugar transport genes. NE768(fruA) exhibited restricted growth in 10 mM fructose. In H441 airway epithelial-bacterial co-culture, elevation of basolateral sugar concentration (5-20 mM) increased the apical growth of JE2. However, sugar-induced growth of NE768(fruA) was significantly less when basolateral fructose rather than glucose was elevated. This is the first experimental evidence to show that S. aureus directly utilises sugars present in the ASL for growth. Interestingly, JE2 growth was promoted less by glucose than fructose. Net transepithelial flux of D-glucose was lower than D-fructose. However, uptake of D-glucose was higher than D-fructose across both apical and basolateral membranes consistent with the presence of GLUT1/10 in the airway epithelium. Therefore, we propose that the preferential uptake of glucose (compared to fructose) limits its accumulation in ASL. Pre-treatment with metformin increased transepithelial resistance and reduced the sugar-dependent growth of S. aureus. Thus, epithelial paracellular permeability and glucose transport mechanisms are vital to maintain low glucose concentration in ASL and limit bacterial nutrient sources as a defence against infection